THE GERMAN "MORAN" PROJECT

The German Academic Publishers Project - Gap

German Academic Publishers (GAP, www.gap-c.de) is a project funded by the Deutsche Forschungsgemeinschaft (DFG, German Science Foundation, www.dfg.de) for the purpose of creating a new model for academic publishing. Activities commenced in December 2001 and funding is secure for two years; a follow-up proposal requesting an extension of funding for additional developments and integration will b...

The historical Moran model

We consider a multi-type Moran model (in continuous time) with selection and typedependent mutation. This paper is concerned with the evolution of genealogical information forward in time. For this purpose we define and analytically characterize a pathvalued Markov process that contains in its state at time t the extended ancestral lines (adding genealogical distances) of the population alive a...

German human methylome project started.

In the December issue of Cancer Research , Jones and Martiensen report on an AACR meeting of scientists interested in DNA methylation and epigenetics (1). The aim of that meeting was to prepare the grounds for a human epigenome project, which is certainly needed as concluded by Rauscher in an editorial in the same issue of Cancer Research (2). In this respect, we would like to announce that the...

The Moran model with selection

Fluctuating Selection in the Moran

Contrary to classical population genetics theory, experiments demonstrate that fluctuating selection can protect a haploid polymorphism in the absence of frequency dependent effects on fitness. Using forward simulations with the Moran model, we confirm our analytical results showing that a fluctuating selection regime, with a mean selection coefficient of zero, promotes polymorphism. We find th...